A Review of the Microcirculation in Skin in Patients With Chronic Venous Insufficiency: The Problem and the Evidence Available for Therapeutic Options
Identifieur interne : 007D52 ( Main/Exploration ); précédent : 007D51; suivant : 007D53A Review of the Microcirculation in Skin in Patients With Chronic Venous Insufficiency: The Problem and the Evidence Available for Therapeutic Options
Auteurs : Uwe Wollina [Allemagne] ; Mohamed Badawy Abdel-Naser [Égypte] ; Raj Mani [Royaume-Uni]Source :
- The International Journal of Lower Extremity Wounds [ 1534-7346 ] ; 2006-09.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Microcirculation.
- physiopathologie : Insuffisance veineuse.
- usage thérapeutique : Préparations à base de plantes.
- Bas de contention, Humains, Insuffisance veineuse, Maladie chronique, Peau, Phytothérapie, Pronostic.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Plant Preparations.
- blood supply : Skin.
- methods : Phytotherapy.
- physiology : Microcirculation.
- physiopathology : Venous Insufficiency.
- therapy : Venous Insufficiency.
- Chronic Disease, Humans, Prognosis, Stockings, Compression.
Abstract
Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO2 and TcPCO2). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.
Url:
DOI: 10.1177/1534734606291870
Affiliations:
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predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO2 and TcPCO2). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>Égypte</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Wollina, Uwe" sort="Wollina, Uwe" uniqKey="Wollina U" first="Uwe" last="Wollina">Uwe Wollina</name></noRegion><name sortKey="Wollina, Uwe" sort="Wollina, Uwe" uniqKey="Wollina U" first="Uwe" last="Wollina">Uwe Wollina</name></country><country name="Égypte"><noRegion><name sortKey="Abdel Naser, Mohamed Badawy" sort="Abdel Naser, Mohamed Badawy" uniqKey="Abdel Naser M" first="Mohamed Badawy" last="Abdel-Naser">Mohamed Badawy Abdel-Naser</name></noRegion><name sortKey="Abdel Naser, Mohamed Badawy" sort="Abdel Naser, Mohamed Badawy" uniqKey="Abdel Naser M" first="Mohamed Badawy" last="Abdel-Naser">Mohamed Badawy Abdel-Naser</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Mani, Raj" sort="Mani, Raj" uniqKey="Mani R" first="Raj" last="Mani">Raj Mani</name></noRegion><name sortKey="Mani, Raj" sort="Mani, Raj" uniqKey="Mani R" first="Raj" last="Mani">Raj Mani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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